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                            "fi": "<jats:p>We examine the physical health consequences to entrepreneurs of firm growth and decline. Using register-based panel data (2000–2021), we find that entrepreneurs and hired CEOs are, on average, healthier and live longer than individuals from a socio-economically similar random sample from the general population. However, our findings also reveal that entrepreneurs are more likely to fall ill during their tenure and die younger than hired CEOs. Importantly, our findings demonstrate that both cumulative exposure to growth and episodic, rapid declines in sales and in the number of employees are equally taxing for entrepreneurs and hired CEOs.</jats:p>",
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                "en": "The aim of the National Aquaculture Strategy 2022 is to increase fish farming in Finland. In 2014, the ministries of Agriculture and Forestry and Environment identified areas where new fish farms can be established (link to the national aquaculture location management plan?). Metsähallitus manages over 2 million hectares of public waters in the sea. A large part of the areas suitable for fish farming are located in ranges under the control of Metsähallitus. The aim of the Aquaculture Innovation Program is to carry out research and development activities which can increase domestic fish farming and its value in a sustainable way. The Aquaculture Innovation Program has developed a fish farm allocation tool, FINFARMGIS. The tool is based on an ecosystem approach which considers the impact of fish farming through different ecological, social and economic criteria. The tool can be used to evaluate production sites by the set criteria or more comprehensively by the environmental permit process. FINFARMGIS is updated as spatial data and research data increases. At the moment location optimization takes the following criteria into account (in brackets criterias still under work): 1. Exclusive criteria: fairways, military areas, national parks, wrecks, cables, private and state nature reserves 2. Ecological guiding criteria: Natura SPA areas,Natura SCA areas, sea area openness, ocean current, ecological status classification, depth, underwater nature peak areas (a-chlorophyll, other fish farms load) 3. Social guiding criteria: recreational facilities (recreational areas and fishing areas) 4. Criteria that guide the economy: distance from the shore (high-efficiency production areas, estimate of sustainable production, fish disease risk) The Government's key project “Pilots of the Environmental Statement” recommends that public institutions make the necessary inquiries and obtain environmental permits for entrepreneurs,. As a result, Metsähallitus, the Natural Resources Center and the Finnish Environment Institute are launching a “Kalavaltio” project, where existing research data will be used to identify new production sites in waters owned and controlled by Metsähallitus. The FINFARMGIS tool is used to define sustainable production areas. Also more detailed studies that are required for the environmental permit will be implemented primarily in areas of interest to entrepreneurs. Entrepreneurs are therefore asked to contact the Natural Resources Center or Metsähallitus if the company is interested in expanding its production in the areas owned and controlled by Metsähallitus. The target areas for the project for more detailed explanations are selected 15.4.2019 based on incoming contacts.\n\n#### Additional Information\n\nMarkus Kankainen ja Lauri Niskanen Luonnonvarakeskus\n\nJani Viisanen Metsähallitus",
                "fi": "Kansallisen vesiviljelystrategian 2022 tavoitteena on lisätä kalankasvatusta Suomessa. Kansallinen vesiviljelyn sijainninohjaussuunnitelma valmistui 2014 Maa- ja metsätalousministeriön ja Ympäristöministeriön yhteistyönä osoittamaan alueita, jonne voi perustaa uusia kalankasvatuslaitoksia. \n\nMetsähallituksen hallinnassa on yli 2 miljoonaa hehtaaria yleisiä vesialueita meressä. Vesiviljelyn sijainninohjaussuunnitelmassa kalankasvatukseen soveltuvat alueet sijaitsevat suurelta osin Metsähallituksen hallinnassa olevilla alueilla. Metsähallitus ja Luonnonvarakeskus arvioivat innovaatio-ohjelmassa yhteistyössä muiden partnereiden kanssa merialueita, jonne tuotantoa olisi mahdollista sijoittaa. \n\nVesiviljelyn innovaatio-ohjelman tavoitteena on toteuttaa tutkimus- ja kehittämistoimia, joilla voidaan lisätä kestävästi kotimaista kalankasvatusta ja sen arvoa. Vesiviljelyn innovaatio-ohjelmassa on kehitetty FINFARMGIS ekosysteemilähestymistapaan perustuvaa kalankasvatuksen sijainninohjaustyökalua, joka ottaa kansallista sijainninohjaussuunnitelmaa tarkemmin huomioon kalankasvatuksen vaikutukset ekologisiin, sosiaalisiin ja taloudellisiin kriteereihin. Jolloin työkalulla voidaan arvioida tuotantopaikkoja kriteerikohtaisesti ja kokonaisvaltaisesti esimerkiksi ympäristölupaprosessissa. \n\nFINFARMGIS tarkentuu paikkatiedon ja tutkimustiedon lisääntyessä ja tarkentuessa. Tällä hetkellä sijainninoptimoinnissa on huomioitu; (suluissa työn alla olevat kriteerit) 1. Poissulkevina kriteereinä; väyläalueet, sotilasalueet, kansallispuistot, hylyt, kaapelit, yksityiset ja valtion luonnonsuojelualueet 2. Ekologisina ohjaavia kriteereinä; Natura SPA alueet; Natura SCA alueet, alueen avoimuus, virtaus, ekologinen tilaluokittelu, syvyys, vedenalaisen luonnon huippualueet (a-klorofylli, muiden kalankasvatuslaitosten kuormitus) 3. Sosiaalisina ohjaavina kriteereinä; vapaa-ajan asutus, (virkistysalueet ja kalastukselle tärkeät alueet) 4. Taloudellisina ohjaavia kriteereitä; etäisyys rannasta ja merialueen avoimuus (lämpötilaltaan tehokkaat tuotantoalueet, arvio kestävästä tuotantomäärä, kalatautiriski) \n\nValtioneuvoston kärkihankkeessa ”Ympäristöluvituksen pilotit” suositus oli, että julkiset instituutiot voisivat tehdä tarvittavat selvitykset ja hakea ympäristöluvat valmiiksi yrittäjille, koska lupaprosessit ovat kalliita ja epävarmoja. Näin ollen Metsähallitus, Luonnonvarakeskus ja Suomen ympäristökeskus ovat käynnistämässä ”Kalavaltio” – hanketta, jossa olemassa oleva tutkimustietoa hyödynnetään uusien tuotantopaikkojen määrittämiseen Metsähallituksen vesialueille. Kestävien tuotantoalueiden määrittämiseen hyödynnetään FINFARMGIS työkalua mutta tarkempia ympäristöluvassa tarvittavia selvityksiä lähdetään toteuttamaan ensisijaisesti alueilla jotka kiinnostavat yrittäjiä. \n\nYrittäjiä pyydetäänkin ottamaan yhteyttä Luonnonvarakeskukseen tai Metsähallitukseen, jos yritystä kiinnostaa tuotantonsa laajentaminen karttalinkkien osoittamilla Metsähallituksen alueilla. Hankkeen kohdealueet tarkempia selvityksiä varten valitaan 15.4. saapuneiden yhteydenottojen perusteella.\n\n#### Lisätietoa\n\nMarkus Kankainen ja Lauri Niskanen Luonnonvarakeskus\n\nJani Viisanen Metsähallitus\n\n[Luken Kalahavainnot-portaali - tietoa Suomen kalahavainnoista ja kalalajeista](https://kalahavainnot.luke.fi)\n\n[Vesiviljelyn sijainninohjaussuunnitelman ympäristöselostus](https://urn.fi/URN:ISBN:978-952-303-155-5)"
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                            "fi": "<jats:title>Abstract</jats:title>\n          <jats:p>Cholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood. Here, we established a hyperspectral stimulated Raman scattering microscopy system to identify and quantitatively assess CEs and TAGs in individual LDs of human cells. We found that nuclear envelope-associated lipid droplets (NE-LDs) were enriched in cholesteryl esters compared to lipid droplets in the cytoplasm. Correlative light-volume-electron microscopy revealed that NE-LDs projected towards the cytoplasm and associated with type II nuclear envelope (NE) invaginations. The nuclear envelope localization of sterol O-acyltransferase 1 (SOAT1) contributed to NE-LD generation, as trapping of SOAT1 to the NE further increased their number. Upon stimulation by the pro-inflammatory cytokine TNFα, the number of NE-LDs moderately increased. Moreover, TNFα-induced NF-κB nuclear translocation was fine-tuned by SOAT1: increased SOAT1 activity and NE-LDs associated with faster NF-κB translocation, whereas reduced SOAT1 activity and NE-LDs associated with slower NF-κB translocation. Our findings suggest that the NE is enriched in CEs and that cholesterol esterification can modulate nuclear translocation.</jats:p>",
                            "und": "<jats:title>Abstract</jats:title>\n          <jats:p>Cholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood. Here, we established a hyperspectral stimulated Raman scattering microscopy system to identify and quantitatively assess CEs and TAGs in individual LDs of human cells. We found that nuclear envelope-associated lipid droplets (NE-LDs) were enriched in cholesteryl esters compared to lipid droplets in the cytoplasm. Correlative light-volume-electron microscopy revealed that NE-LDs projected towards the cytoplasm and associated with type II nuclear envelope (NE) invaginations. The nuclear envelope localization of sterol O-acyltransferase 1 (SOAT1) contributed to NE-LD generation, as trapping of SOAT1 to the NE further increased their number. Upon stimulation by the pro-inflammatory cytokine TNFα, the number of NE-LDs moderately increased. Moreover, TNFα-induced NF-κB nuclear translocation was fine-tuned by SOAT1: increased SOAT1 activity and NE-LDs associated with faster NF-κB translocation, whereas reduced SOAT1 activity and NE-LDs associated with slower NF-κB translocation. Our findings suggest that the NE is enriched in CEs and that cholesterol esterification can modulate nuclear translocation.</jats:p>"
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